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The brain is made up of nerve cells (neurons), among other things. Activity, by which I assume you mean motor activity, is regulated by neuronal systems in the precentral gyrus, which is also referred to as the motor cortex. Damage to the motor cortex will cause paralysis on the opposite side of the body (i.e., damage to the right motor cortex causes paralysis on the left side of the body, and vice versa).

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