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Integrity testing for sterilizing grade filters is a non-destructive test of importance to evaluate whether or not the filter is integral, i.e. damaged, flawed or of the right pore size. The integrity test of a sterilizing filter has to be performed post-filtration (regulatory requirement) and can be used pre-use. The typical integrity tests performed are diffusive flow (aka forward flow), pressure hold (aka pressure decay or pressure drop) and Bubble Point. There are two specific tests; water intrusion test for hydrophobic vent filters and multi-point diffusion test for validation or analytical purposes. Most of the time automatic integrity test systems are used as these have a higher precision than manual tests.

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Q: What is intrigity test for sterile filtration?
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