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Large offspring is a phenonenom which is found mainly in cloned lambs and calves which are the result of embryo manipulation (IVF) (NT). The phenomenon creates oversized offspring due to insulin like growth factor 2 receptor (IGF2R) making protein which blocks the normal growth of cells. When the receptor is deactivated the embryos grow too large. Other symptoms can include enlarged hearts, immature lungs and damaged kidneys. It has not been seen in humans due to IGF2R unable to be deactivated. Large offspring is thought to be a result of the environment the embryos are grown in in both the lab and the donor mother.

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Q: What is large offspring syndrome?
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