Large offspring is a phenonenom which is found mainly in cloned lambs and calves which are the result of embryo manipulation (IVF) (NT). The phenomenon creates oversized offspring due to insulin like growth factor 2 receptor (IGF2R) making protein which blocks the normal growth of cells. When the receptor is deactivated the embryos grow too large. Other symptoms can include enlarged hearts, immature lungs and damaged kidneys. It has not been seen in humans due to IGF2R unable to be deactivated. Large offspring is thought to be a result of the environment the embryos are grown in in both the lab and the donor mother.
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No, CFC syndrome is caused by a sporadic mutation.
As the disease is genetic, DS women have nearly a 50% chance of passing on DS to their offspring if the father does not have DS.
Not usually. Only In certain circumstances, can a mutation be passed on to offspring; such as Downs-syndrome.
No, because people with Down syndrome can't have children.
No.
Down's Syndrome is caused mainly by a mutation in the gene. It is a genetic disorder, which means it was passed on from parents to offspring.
Marfan syndrome is an autosomal dominant disorder. An affected person has a 50% chance of passing it on to each offspring, regardless of gender.
No. Parents of Down Syndrome typically are normal genetically and there is no test for parents to determine the possibility of a Down Syndrome offspring. There are no known external factors that are known to contribute to Down Syndrome. It is possible to test for Down Syndrome in the fetus.
This syndrome is caused by a new mutation in one or two genes in 60% of the cases. These are not inherited. The other 20% are inherited if one parent carries the mutated gene. In the final 20% both parents have to carry a different gene for their offspring to have the syndrome. In this case neither parent show any signs or symptoms.
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Coffin-Lowry syndrome is an x-linked dominant condition which means it can only be passed on by a female. There are no known instances of a man passing CLS on to offspring. If the mother has CLS or is a CLS carrier, then there is a 50/50 chance of passing on the condition to her offspring. CLS can also occur as a spontaneous mutation, where there is no family history of the condition.