People often have different common names for these: clot-busters or blood thinners. They make the clotting time longer and so slow down coagulation.
Carbon monoxide inhibit blood platelet aggregation.
A chemical that is added to the blood sample in the platelet aggregation test to stimulate the clumping process.
Platelet Count
aids in the evaluation of bleeding disorders by measuring the rate and degree to which platelets form a clump (aggregate) after the addition of a chemical that stimulates clumping (aggregation).
aspirin decrease platelet aggregation
An aminochromone is an amino derivative of a chromone, some of which block human platelet aggregation.
The platelet aggregation test uses a machine called an aggregometer to measure the cloudiness (turbidity) of blood plasma
Aspirin works by blocking an enzyme called cyclooxygenase, which is needed for the production of certain chemicals that promote platelet aggregation. By inhibiting this enzyme, aspirin helps prevent platelets from sticking together and forming blood clots.
An inhibitor of phosphodiesterase activity would increase the levels of cyclic AMP and/or cyclic GMP in the cell. This may lead to prolonged signaling cascades, affecting various physiological processes such as smooth muscle relaxation, platelet aggregation, and neurotransmitter release.
Aspirin (acetlysalicylic acid) is an irreversible inhibitor of the cyclo-oxygenase (COX-I and COX-II) enzymes which are responsible for the conversion of arachidonic acid into the prostaglandins. It is supposed that this happens due to the acetylation effects of aspirin.
drugs that can decrease platelet aggregation include aspirin, some antibiotics, beta blockers, dextran (Macrodex), alcohol, heparin (Lipo-Hepin), nonsteroidal anti-inflammatory drugs (NSAIDs), tricyclic antidepressants, and warfarin
Prostacyclin (PGI2) opposes the action of thromboxane A2. They are both derived from arachidonic acid and have opposite effects on platelet aggregation and blood clot formation. Prostacyclin acts as a vasodilator and inhibits platelet aggregation, counteracting the pro-thrombotic effects of thromboxane A2.