Neuroleptic-- Another name for the older type of antipsychotic medications given to schizophrenic patients.
Neuroleptics in general.
neuroleptics
Use of certain antipsychotic drugs, or neuroleptics, can induce dystonia.
Medications, such as antipsychotics and neuroleptics, have been used to treat stuttering with limited success.
Cholinesterase inhibitors and NMDA receptor antagonist for mainly cognition, neuroleptics for aggression and agitation, and antidepressant. Behavioral therapy is effective for programmatic behaviors such as wandering, hoarding, hiding objects, or repetitive questioning.
The theory behind why individuals develop 'psychotic' symptoms is based upon the idea that there are elevated levels of dopamine in the brain. Dopamine is a neurotransmitter, a molecule that passes messages between neurons. For example, when a nerve impulse arrives at a dopaminergic neuron (also known as a pre-synaptic neuron), dopamine is released from the cell and diffuses through a space between two neurons, called the synaptic cleft. Dopamine then binds to specific dopamine receptors on a different neuron (post-synaptic neuron) producing a specific signal, impulse or effect. Dopamine is then released from its receptors and 're-absorbed' into the pre-synaptic neuron, or degraded by enzymes in the synaptic cleft. The neuroleptics block dopamine receptors thereby inhibiting the ability of dopamine to attach to these receptors and generate signals. However, unlike the typical neuroleptics, the atypicals merely transiently block the receptors therefore allowing some dopamine to bind to the receptors and generate signals. The atypical neuroleptics are also able to block serotonin receptors located on dopaminergic neurons. When serotonin binds to these receptors it inhibits dopamine release. However as these receptors are blocked by atypical neuroleptics, the dopamine secretion is increased. The transient rather than permanent blocking of dopamine receptors and the blocking of serotonin receptors and subsequent increases in dopamine, it is for these reasons that the atypicals are thought to produce fewer adverse effects than the typical neuroleptics. However, the atypical drugs differ in their 'stickyess' when binding to dopamine receptors and also in the ratio of which dopamine ad serotonin receptors are affected. This may result in some atypicals producing higher levels of specific adverse effects than others. The atypicals may also bind to other receptor types, producing further adverse effects (see side effects of atypicals section).
Anti-psychotic agents (with second generation atypicals or SGA agents being the most common, nowadays). SGA Agents include Risperdal, Zyprexa, Seroquel, Geodon, Abilify, and Saphris. Neuroleptics
Neuroleptic drugs-- Antipsychotic drugs, including major tranquilizers, used in the treatment of psychoses like schizophrenia.
R.W. Shayer discovered histamine and brought about the original neuroleptics in pharmacology; he was a chemist. Most of his discoveries were in the 1950's.
Neuroleptics, or antipsychotics, are the drugs most commonly used to treat schizophrenia. They block the dopamine pathways to reduce the amount of dopamine in the brain, which could be one cause of the schizophrenia. However, it's difficult to get patients to stay on their medication because of the unpleasant side effects.
A stroke occurs when there is an interruption of blood flow to the brain, leading to brain damage. This interruption can be caused by a blockage in a blood vessel (ischemic stroke) or the rupture of a blood vessel (hemorrhagic stroke). Strokes can result in various symptoms, such as weakness on one side of the body, speech difficulties, and altered mental status.
The use of anticholinergic medications (eg. benztropine) is the treatment of choice as pseudoparkinsonism is caused by neuroleptics/antipsychotic medications that decrease dopamine activity in the brain. As you can't you the typical treatment for parkinsonism (ie. increase dopamine activity - as this would abolish the effect that you are trying to have with the antipsychotics) the only choice left is to reduce the activity of acetylcholine or adjust the dose of the antipsychotic medication to an alternative and hope that the side effects are lessened on the new medication. Hope this helps