The pKa values of Amino acids depends on its side chain. However, the protonated amine group (NH3+) tends to have a pKa greater than 8.8, whereas the carboxylic acid (COOH) tends to have a pKa of 1.8 - 2.8. If you keep your amino acid at a pH between this value, you will likely have a Zwitter ion.
Doxofylline Pka value is about 9.8.
pKa = 15
It is around pKa=13
The pka of a protonated ether (the conjugate acid) is about -3.5
7.6
Doxofylline Pka value is about 9.8.
pKa = 15
It is around pKa=13
By following + or - 2 pH to the pKa value
The pka of a protonated ether (the conjugate acid) is about -3.5
The conjugate acid is Hydrogen (H2), the pKa of which is 35.
3.3
7.6
if Pka value is more for acidic drug,best side for absorption will be throughout the G.i.Tract.
pKa = 6.36 of carbonic acid to HCO3-
actual pka of betaxolol is 9.4 but observed is 9.38
The pKa of sulfonic acid is < 0