The pka of a protonated ether (the conjugate acid) is about -3.5
Doxofylline Pka value is about 9.8.
pKa = 15
It is around pKa=13
By following + or - 2 pH to the pKa value
The conjugate acid is Hydrogen (H2), the pKa of which is 35.
3.3
7.6
if Pka value is more for acidic drug,best side for absorption will be throughout the G.i.Tract.
pKa = 6.36 of carbonic acid to HCO3-
actual pka of betaxolol is 9.4 but observed is 9.38
The pKa of sulfonic acid is < 0
A pKa value is a measurement used for bases and acids. The measurement pH applies to hydronium ion concentrations that are in a solution, whereas pKa only applies to determining the amount of dissociation an acid wants to do in a solution.