An agonist stimulates the receptor, whereas an antagonist blocks a receptor.
Muscimol is a GABA A agonist effet psychotomimetic
An agonist binds to a receptor and stimulates it (turns it on). An antagonist binds to a receptor and blocks it from being activated by other molecules (turns it off).
Cocaine is an agonist to the dopamine receptor. Because it is an agonist, cocaine sits on the dopamine receptor, thus inducing dopamine chemicals to flood into the brain and body. Dopamine makes a person feel euphoria......
There are natural muscarinic receptor agonist that might treat anhidrosis. One the best natural agonist of muscarinic is known as acetyl choline.
We mostly talk about agonists and antagonists with regards to cellular receptors. An agonist binds to a receptor and activates it, an antagonist binds to the receptor, but DOES NOT activate it, and prevents it from being activated.
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An agonist is a chemical that binds to a receptor of a cell and triggers a response by the cell. An agonist often mimics the action of a naturally occurring substance.
Zomig (zolmitriptan) is a serotonin receptor agonist, used to treat migraines.
Pilocarpine is actually a Muscarinic cholinergic receptor (mAChR) agonist. It works on the Parasypathetic nervous system; therefore, it makes sense that the agonist working on the PNS would result in decreased heart rate. Atropine, in contrast, is an muscarinic cholinergic receptor antagonist and will lead to increased heart rate due to the lowered effect of the parasympathetic system on the heart.
Goserelin is an GnRH receptor agonist and bings stronger than GnRH. Due to the constant activation of the GnRH receptor (Goserelin binds really strong; Superagonist) the cell internalizes the receptor -> Downregulation.
Depending on the hallucinogen, it may be either an agonist or an antagonist at certain receptors. Classic psychedelics such as LSD and psilocybin are 5-HT2A receptor agonists, whereas dissociatives (PCP, DXM, ketamine, etc.) are NMDA receptor antagonists. Deliriants, such as atropine and scopolamine, are muscarinic antagonists.