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Samoyed Hereditary Glomerulopathy is a genetically linked disease that is carried by females and only severely affects males. Male dogs who have the disease first appear healthy, but after 3 months symptoms begin to appear and worsen with time. These dogs usually die by 15 months from renal failure. Female carriers may exhibit mild symptoms of the disease, but these are not fatal.
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What has the author Paul Scott Thorner written?
Paul Scott Thorner has written: 'Samoyed hereditary glomerulopathy: an animal model for human hereditary nephritis'
What is samoyed hereditary glomerulopathy?
Samoyed Hereditary Glomerulopathy is a genetic disease that more severely affects males. Male dogs appear healthy for the first three months of life, but then the dog becomes lethargic and begins to go into renal failure. Death from renal failure usually occurs by 15 months of age.
How is samoyed hereditary disease carried?
Samoyed Hereditary Glomerulopathy is caused by an X-linked dominant faulty allele, and only severely affects male dogs (renal failure). Females who carry the gene can develop mild symptoms, but these are not fatal. When a female carrier is bred with a healthy male, the offspring have a 50% chance of having the faulty allele.
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