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  1. Take I-55 SOUTH through Missouri, Arkansas, Tennessee (Memphis) and Mississippi (through Jackson) to I-12 EAST to SLIDELL at EXIT 29A in Louisiana.
  2. Take I-12 EAST to I-10 EAST to BAY St. Louis at EXIT 85C.
  3. Take I-10 EAST through Louisiana, Mississippi and Alabama to Pensacola and I-110 (EXIT 12) will take you right into downtown and it will also take you to the beaches.
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Q: What is the best route from St Louis to Pensacola Florida?
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