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Take U.S. 219 SOUTH to the EXIT for I-70/76 Pennsylvania TURNPIKE (toll road) to PITTSBURGH and HARRISBURG in southern Pennsylvania. This is in Somerset.

Exit off U.S. 219 and then follow signs to I-70/76 PENNSYLVANIA TURNPIKE (toll road). Once you are at the Turnpike and once you are past the toll booth, follow signs to I-70/76 EAST to HARRSIBURG and PHILADELPHIA.

Take I-70/76 EAST on the PENNSYLVANIA TURNPIKE (toll road) to U.S. 30 TO I-70 EAST to BREEZEWOOD and BALTIMORE.

Exit off the Turnpike and FOLLOW SIGNS to I-70 EAST.

Take I-70 EAST to I-270 SOUTH to WASHINGTON at EXIT 53 in Maryland.

Take I-270 SOUTH to Washington, D.C.

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Q: What is the best route to take from Buffalo NY to Washington D.C.?
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