I-85 S to I-77 S to I-26 E to I-95 S
Greensboro, NC is about halfway but it can depend on the route you take
The fastest route to drive from Orlando Florida to Jacksonville Florida is on a US Interstate highway. In this case that highway is Rt. 95.
I-85 South through Durham, Greensboro, and Charlotte.
Longest route is 1,200 miles
I-10 all the way
its about 257 miles depending on the route you take!
On the route suggested by Google maps half way is Greensboro
oakville ontario to daytona
I-95 south to Jacksonville I-75 south to Tampa
jacksineville
The halfway point between Jacksonville, Florida and Sandusky, Ohio is Estatoe, North Carolina (depending on your exact route of course.
195 miles taking this route:Take I-464 SOUTH from Norfolk to ROUTE 168 SOUTH; take ROUTE 168 SOUTH to the FIRST EXIT, which is U.S. 17 SOUTH to ELIZABETH CITY.Take U.S. 17 SOUTH to Jacksonville.