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  1. Take I-95 NORTH through Florida and Georgia to I-26 WEST to COLUMBIA at EXIT 86B in South Carolina.
  2. Take I-26 WEST to I-77 to CHARLOTTE at EXIT 116 outside of Columbia.
  3. Take I-77 NORTH through South Carolina, North Carolina, Virginia and West Virginia to I-70 WEST to COLUMBUS at EXIT 44B (LEFT EXIT) in OHIO.
  4. Take I-70 WEST to Columbus.
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Q: What is the best way from Daytona Beach Florida to Columbus Ohio?
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It is 950 miles taking this route:Take I-95 NORTH, from Daytona Beach, to I-26 WEST to COLUMBIA at EXIT 86B in SOUTH CAROLINA.Take I-26 WEST to I-77 to CHARLOTTE at EXIT 116.Take I-77 NORTH to I-70 WEST to COLUMBUS at EXIT 44B in OHIO.Take I-70 WEST to COLUMBUS.


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