Passenger trains do not serve Nashville, Tennessee.
Interstate 40 runs from all the way from Barstow, CA to Nashville. That's the easiest and fastest. You get to I-40 from I-15.
Interstate 95
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getting a four wheel drive would help a lot
If you don't drive, the best way is by train
None! Both highways stop in different cities. I 65 end in Nashville and I 57 ends in a town called Sikeston.
I'd say that the best way to travel would be to the west...
carefully
Drive slower.
Nashville, TN Metropolis, IL Atlanta, GA There are lots of places on the way to visit and see fun things. Its a long drive. Heck, Even the Chattanooga ChooChoo is on the way.
One of the best ways to move is to drive between the two places. If you have a lot of stuff, you can drive a moving truck.