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No danger other than the side effects listed for each. Wellbutrin+nalextrone is Contrave, a weight loss drug close to FDA approval. A possible side effect of trazodone is weight gain so if using wellbutrin/ nalextrone for that, you may want to check w you dr about adding trazodone

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Q: What is the danger in mixing Wellbutrin Naltrexone and Trazadone?
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I had side effects , i started putting on weight, and did not get a permenant cure but i got this blog which really helped me to cure the panic attack http://trainyourmind.blogspot.com -------------------- I have been on lexapro 20mg and wellbutrin 150mg for about 6 months for depression and anxiety. Mixing these two has helped me with both mood and lack of attention/energy in my case. My impression is that Lexapro works pretty well with mood and anxiety, and wellbutrin helps attention, energy, sex drive, and concentration. So there are other symptoms like fatigue and lack of motivation left, but we know that anti-depressants don't attack all depressive symptoms.