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What is the difference between a class I MHC mechanism vs a class II MHC mechanism?
Wiki User
∙ 9y ago
The Class I MHC molecules process endogenous(intracellular) peptides/antigens whereas the Class II process exogenous(extracellular) peptides/antigens.
The Class I molecules are assembled and located in the ER whereas the Class II are assembled in the ER but located in the endosomes.
When extracellular peptides are taken into the cell via receptor mediated endocytosis or phagocytosis, they will be transported into the endosomes and get degraded. This will enable the peptide generated to be loaded onto the Class II molecules.
For Class I, when a bacteria or virus infect a cell, they will replicate and produce proteins. These proteins will be ubiquitinated and degraded by the proteasome. This smaller peptides can then be transported into the ER via the TAP transporters, that are complexed with the Class I molecules, to be loaded onto the Class I molecules.
Wiki User
∙ 9y ago
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What is the difference between MHC and HLA?
MHC (major histocompatability complex) is the term for the molecules in all vertebrates. HLA (human leukocyte antigen) is the specific term for that class of molecules in humans.
What is the difference between T cell receptors and MHC molecules?
T cell receptors bind to MHC class 1 molecules. MHC class 1 molecules bind to peptides (self or foreign) and present it to the cell's membrane. The job of a T cell is to decide what is presented on the MHC class 1 cell whether to leave it alone or to activate to destroy it because it is non-self.
Do neurons have mhc class 1 receptors?
All cells with a nuclei have MHC class 1.
Is MHC class 1 the same as HLA class 1?
The answer previously here about MHC referring to mice and HLA referring to humans is catagorically untrue! HLA and MHC are in fact the same, so HLA class 1 = MHC class 1. Same goes for class 2.
Difference between MHC class1 and MHC class2 molecules?
MHC proteins express antigens on a cell surface for T cells to identify whether the antigens presented are self or foreign. There are two classes MHC I and MHC II. They differ in which cells they require to activate depending on the pathogen present.
What is the role of cytotoxic T cells and describe their mechanism of action?
The role of cytotoxic T cells is to alert Class I MHC molecules to a foreign antigen. This is achieved by the foreign antigen associating with the MHC molecule and being moved out to the cell surface, where the cytotoxic T cell alerts the MHC molecule of the infection.
Which class of MHC proteins presents exogenous antigens?
Class ll
When an antigen binds to a Class 1 MHC molecule it stimulates what cell?
Class I MHC molecules present antigens to cytotoxic T-cells (which are CD3+CD8+).
Where are major histocompatibility complex-you MHC-you molecules located?
Each individual has a unique MHC profile Clinically important MHC are HLA(human leukocyte antigens) -A, -B -DR -expression of a particular combination of MHC genes Class I - are located on all nucleated cells Class II - are located on macrophages, dendritic cells, B cells.
Major histocompatibility complex serves as the identification fingerprint for?
Well, there is not really a short answer for it: 1) there are 2 class of MHC: HLA/MHC-I: binds to CD8 T cells HLA/MHC-II: binds to CD4 T cells A physician has to check for a good match of the MHC subtypes in a transplation between graft and host. A good match reduces the risk of immune complications after the transplantation.
Class II MHC molecules are found only on which of the following?
Presented by APCs as MHC-exogenous peptide complex
Where are Class II molecules found?
Presented by APCs as MHC-exogenous peptide complex
