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Presented by APCs as MHC-exogenous peptide complex

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Karelle Grady

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3y ago

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major class of molecules found in egg yolk


Class II MHC molecules are found only on which of the following?

Presented by APCs as MHC-exogenous peptide complex


What is the difference between a class I MHC mechanism vs a class II MHC mechanism?

The Class I MHC molecules process endogenous(intracellular) peptides/antigens whereas the Class II process exogenous(extracellular) peptides/antigens. The Class I molecules are assembled and located in the ER whereas the Class II are assembled in the ER but located in the endosomes. When extracellular peptides are taken into the cell via receptor mediated endocytosis or phagocytosis, they will be transported into the endosomes and get degraded. This will enable the peptide generated to be loaded onto the Class II molecules. For Class I, when a bacteria or virus infect a cell, they will replicate and produce proteins. These proteins will be ubiquitinated and degraded by the proteasome. This smaller peptides can then be transported into the ER via the TAP transporters, that are complexed with the Class I molecules, to be loaded onto the Class I molecules.


What is the type of major histocompatibility marker that's most likely found on a liver cell?

Answer Class II MHC protein. Class II are found in membranes of antigen-presenting cells-phagocytic cells and lymphocytes. The liver performs phagocytosis and antigen presentation.


Difference between MHC class1 and MHC class2 molecules?

MHC proteins express antigens on a cell surface for T cells to identify whether the antigens presented are self or foreign. There are two classes MHC I and MHC II. They differ in which cells they require to activate depending on the pathogen present.


What role does the macrophage play in?

presents antigens of an engulfed pathogen in its class II MHC molecules to helper T cells, and releases IL-1


Is HLA only found on leukocytes?

HLA (human leukocyte antigen) is the name for the MHC (major histocompatibility complex) found in humans.  MHC class I molecules (HLA-A, HLA-B, HLA-C) are found on pretty much all cells (some important exceptions are red blood cells).  MHC Class II molecules (HLA-DQ, HLA-DP, HLA-DR) are found on special antigen presenting cells, which include B-lymphocytes, dentritic cells, and macrophages.


When was DRG Kleinlokomotive Class II created?

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Can a Class II ball mount can be used with a Class III receiver hitch.?

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