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To rein is to hold something back: When the horses go too fast, I rein them in.

To reign is to rule: Alexander the Great reigned over most of his known world.

A rein is a leather strap, or a similar (metaphorical) restriction. It's often used in the plural: Grab the reins!or I gave her free rein to do what she needed.

A reign is a period of rule: Queen Elizabeth's reign has lasted almost 60 years.

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Q: What is the difference between rein and reign?
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