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How is the DNA in the Sickle Cell allele different from the normal allele?
Wiki User
∙ 13y ago
Normally, the 6th position of the beta chain of hemoglobin is a Glutamic acid, encoded on the DNA as GAG. The sickle cell mutation has the sequence GTG, resulting in a Valine in the 6th position instead.
Wiki User
∙ 16y ago
Wiki User
∙ 14y agoThere is one main difference between sickle cells and normal cells, sickle cells, created in a sickle or crescent shape, while normal cells are shaped like doughnuts. As a result of the shape of the sickle cells, they can only carry a fractional amount of oxygen and nutrients. So people effected by sickle cell anemia, suffer from shortness of breath and weakness.
See related link for picture of sickle cell and normal cell
Wiki User
∙ 13y agoit has less, DNA, and, the sickle-cell is half the size of a regular cell
Wiki User
∙ 11y ago21
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The allele for the sickle cell trait is what with the normal allele?
codominant
How would you describe what an allele is?
*An allele is basically the different forms a particular gene can take (describes the various genotypes/phenotypes a gene can take).* For example there is an allele of a gene which codes for haemoglobin in red blood cells, which gives them their characteristic concave shape. But there can also be a mutation in that gene, which causes a different allele to be produced which gives it a sickle-cell shape, which leads to sickle-cell anaemia.
What would happen to a baby in the womb if the mother has sickle cell disease and the father has the sickle cell trait?
If both parents are trait carriers the chances of them having a child WITH sickle cell is 4 to 1. Probability says, 1 will not carry the trait OR have sickle cell, 2 will be trait carriers and 1 will have it. But Keep in mind that every time you have a child its like rolling dice. I have heard of people where all four kids have the disease. and i have 2 children with the disease and 1 that's normal.
Involves placing a normal allele in a cell that has a mutation and hoping that the normal allele begins to function?
Gene therapy
This pedigree is for a human genetic disease called sickle cell anemia. Assuming that the allele for the disease is recessive how many of the females shown have the disease?
None. =]
What allele for the sickle cell trait is with the normal allele?
codominant
What is the allele for sickle cell trait with the normal allele?
codominant
The allele for the sickle cell trait is what with the normal allele?
codominant
What are the pros for SICKLE CELL ANEMIA?
The pro of sickle cell hemoglobin is that if you have only one allele for sickle cell hemoglobin and the other allele is normal, then you are immune to malaria.
Heterozygous persons with one sickle cell allele and one normal allele also show resistance to?
Malaria
Can give example about overdominance?
Overdominance is when the heterozygote has an advantage over both the recessive and dominant homozygotes. Sickle cell disease is an example of this. When the individual is homozygous for the sickle cell allele, sickle cell disease is shown. When the the individual is homozygous for the wildtype allele, they appear normal. However, when the individual is heterozygous, he or she appears normal and will also be resistent to malaria.
If malaria were eliminated how might the frequency of the sickle-cell allele change over time?
Since people with the sickle cell allele trait are resistent to malaria, if malaria were eliminated there would be no change in the frequncy of sickle cell allele. This is because the presense of malaria does not have an affect on patients with the sickle cell allele trait.
Compare the normal allele for hemoglobin with the sickle cell allele How does this difference affect the persons red blood cells?
The amino acid sequence of the sickle cell allele for hemoglobin varies from the normal allele for hemoglobin by one amino acid. The sickle cell allele for hemoglobin has valine instead of glutamic acid. When the oxygen level of the blood decreases, the hemoglobin molecules come out of solution, stick together, and form long chains that cause the red blood cells to become sickle shaped.
How would you describe what an allele is?
*An allele is basically the different forms a particular gene can take (describes the various genotypes/phenotypes a gene can take).* For example there is an allele of a gene which codes for haemoglobin in red blood cells, which gives them their characteristic concave shape. But there can also be a mutation in that gene, which causes a different allele to be produced which gives it a sickle-cell shape, which leads to sickle-cell anaemia.
For sickle-cell disease assume S is the dominant allele and s the recessive allele Which genotypes are possible for offspring of a carrier (Ss) and a person who lacks the sickle-cell allele (SS)?
SS,Ss
How does balancing selection affect the sickle cell allele in central Africa?
The sickle cell allele can be maintained in the central African population, above the frequency of gene mutation (balancing selection), because the heterozygous sickle cell individuals have an advantage in lifespan, in this malaria stricken region, over the homozygous alternatives. Homozygous sickle-sickle individuals die early from the sickle cell disease. Homozygous nonsickle-nonsickle die early from malaria. The heterozygous sickle-nonsickle have a higher survival against malaria and therefore the sickle cell allele is balanced selected.
Does sickle cell disease require two allele or multiple alleles?
Sickle cell disease is an autosomal reccessive sexlinked trait so, a female msut have 2 recessive alleles to have the trait and a male needs only one allele (this is because there is no corresponding site for this allele on the Y chromosome. The female can be a carrier of the disorder with the defective allele on one X chromosome and a normal allele on the other X chromosome. Female carrriers can have a mixture of normal and abnormal redblood cells.
