0
What is the difference between whole cell pertussis and acellular pertussis?
Wiki User
∙ 11y ago
There was no statistical difference in mouse protective potency between these acellular or whole cell pertussis vaccines. 2. There were no differences in chemical ingredients between acellular and whole cell pertussis vaccines except for protein nitrogen content. The protein nitrogen content of whole cell vaccine was at least three times higher than that of the acellular product. 3. Anti-PT antibody productivity of the acellular vaccine was higher than that of the whole cell vaccine. 4. Anti-agglutinogen antibody productivity of the whole cell vaccine was higher than that of the acellular vaccine. 5. There was no pyrogenic activity with the acellular vaccine, but high pyrogenicity was seen with whole cell vaccine. 6. There was high body-weight decreasing toxicity in mice and guinea pigs by the whole cell vaccine. 7. The mice died when they received whole cell pertussis vaccine iv, but no deaths occurred in the mice which received acellular pertussis vaccine.
Wiki User
∙ 11y ago
Add your answer:
Earn +20 pts
Who invented dpt vaccine?
This information came from Wikipedia under the heading of PERTUSSIS. It lists the scientists who contributed to the development of the DTP vaccine. The story of this vaccination is long and this was the shortest writing I could locate for you. The World Health Organization contributed to this information and the development of this vaccine.B. pertussis was isolated in pure culture in 1906 by Jules Bordet and Octave Gengou, who also developed the first serology and vaccine. The complete B. pertussis genome of 4,086,186 base pairs was sequenced in 2002.Infection with pertussis induces immunity, but not lasting protective immunity, and a second attack is possible.[15] Efforts to develop an inactivated whole-cell pertussis vaccine began soon after B. pertussis was grown in pure culture in 1906. In the 1920s Dr. Louis W. Sauer developed a vaccine for whooping cough at Evanston Hospital (Chicago, IL). In 1925, the Danish physician Thorvald Madsen was the first to test a whole-cell pertussis vaccine on a wide scale.[16] He used the vaccine to control outbreaks in the Faroe Islands in the North Sea. In 1942, the American scientist Pearl Kendrick combined the whole-cell pertussis vaccine with diphtheria and tetanus toxoids to generate the first DTP combination vaccine. To minimize the frequent side effects caused by the pertussis component of the vaccine, the Japanese scientist Yuji Sato developed an acellular pertussis vaccine consisting of purified haemagglutinins (HAs: filamentous HA and leucocytosis-promoting-factor HA), which are secreted by B. pertussis into the culture medium. Sato's acellular pertussis vaccine was used in Japan since the autumn of 1981.[17] Later versions of the acellular pertussis vaccine used in other countries consisted of additional defined components of B. pertussisand were often part of the DTaP combination vaccine.
How was the pertussis vaccine created?
A number of people were involved in the production of this bacterial vaccine. In the 1920' Dr. Sauer and Dr. Madson. Both of these were whole cell vaccines. Dr. Sato in Japan developed an acellular vaccine and it has been widely used in Japan since 1980. The effectiveness of these two last 3-6 years so boosters are needed.
What is the difference between a whole number a?
A question about "the difference between" requires two objects!
What is the difference between a diameter and a radius?
A diameter is a whole line and a radius is just half not a whole that is the difference
What are the difference between comparing whole number and comparing decimals?
There is no difference.
The difference between two whole numbers is always a whole number?
True.
Is the difference between 2 whole numbers always a whole number?
Yes, it is.
What are the difference between integer and a whole number?
There are no differences.
What is the difference between 0.3 and 3.0?
0.3 is not a whole number and 3.0 is a whole number
What is the difference between a whole number and integer or is it the same?
The same
What is the difference between whole grain and brown rice?
There is no differrence .
What is difference between number and integer?
an integer is a whole number
