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The driving distance between Knoxville, TN and Memphis, TN is approximately 390 miles. The driving time would be approximately 6 hours 15 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work and rush hour traffic in urban areas.)

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Q: What is the driving distance between Memphis and Knoxville?
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