The driving distance between Des Moines, IA and St. Louis, MO is approximately 340 miles. The driving time would be approximately 6 hours 15 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)
About 155 miles.
The driving distance from Chicago, Illinois to Des Moines, Iowa is 334 miles per MapQuest. The driving time per MapQuest is 5 hours and 8 minutes.
The driving distance from Elkhart, Indiana to Des Moines, Iowa is 430 miles via I-80 W per MapQuest. The driving time per MapQuest is 6 hours and 38 minutes.
The driving distance from Ames, Iowa to Des Moines, Iowa is 35 miles via I-35 S per MapQuest. The driving time per MapQuest is 35 minutes.
The driving distance with the shortest travel time is about 211 miles.
900 miles
The driving distance from Florence, Iowa to Des Moines, Iowa is 93 miles via I-35 S per MapQuest. The driving time per MapQuest is 1 hour and 36 minutes.
The driving distance from Clinton, Iowa to Des Moines, Iowa is 199 miles via I-80 W per MapQuest. The driving time per MapQuest is 3 hours and 2 minutes.
St. Louis, Springfield, Peoria, Davenport, Des Moines, Omaha, Kansas City, Topeka, Wichita
The flight distance is 232 miles. The driving distance is 245 miles.
It is 193.91 miles according to MapQuest.
The driving distance from Collins, Mississippi to Des Moines, Iowa is 887 miles via I-55 N to IA-163 W per MapQuest. The driving time per MapQuest is 13 hours and 42 minutes.