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What is the evidence that the MLS resistance in staphylococci originated in Streptomyces erythreus?
Wiki User
∙ 13y ago
Streptomyces erythreus naturally produces macrolide antibiotics. It must have a protection mechanism so its protein does not attack itself. This mechanism is most commonly methylation of the 23S rRNA target, and an efflux pump for macrolides.
The mechanism of resistance in MLS Staphylococci is the same as Strep erythreus. It is more likely the bacteria shared a simple gene that codes for these resistance mechanisms rather than staph naturally becoming resistant for no competitive reason.
Wiki User
∙ 13y ago
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What Abelardo Aguilar did invent?
Abelardo Aguilar participated in the discovery of erythromycin by sending soil samples from the Philippines to his employer, Eli Lilly, where the research team isolated Erythromycin from the metabolic products of a strain of Streptomyces erythreus found in the soil sample.
What antibiotic did filipino doctor abelardo aguilar co-discover?
Doctor Abelardo Aguilar co-discovered the antibiotic called erythromycin. In 1949, Dr. Aguilar shipped soil sample that contained a strain Streptomyces erythreus to Eli Lillyâ??s research team. This antibiotic was isolated from this strain.
Who was the filipino doctor who discovered the antibiotic erythromycin?
The Filipino Doctor discovered the antibiotic Erythromycin was Dr. Abelardo Aguilar sent some soil samples to his employer Eli_Lilly_and_Companyin 1949. Eli Lilly's research team, led by J. M. McGuire, managed to isolate Erythromycin from the metabolic products of a strain of Streptomyces erythreus (designation changed to "Saccharopolyspora erythraea") found in the samples.Lilly filed for patent protection of the compound and U.S. patent 2,653,899 was granted in 1953. The product was launched commercially in 1952 under the brand name Ilosone region of where it was originally collected from). Erythromycin was formerly also called Ilotycin.Erythromycin is an antibiotic (trade name Erythrocin or E-Mycin or Ethril or Ilosone or Pediamycin) obtained from the actinomycete Streptomyces erythreus; effective against many Gram-positive bacteria and some Gram-negative and is often used for people who have an allergy to penicillins.
