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What is the function of HbF?

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Anonymous

12y ago
Updated: 8/20/2019

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Why fetal hemoglobin is not affected by sickle cell disease?

Fetal hemoglobin (HbF) is composed of two alpha and two gamma chains, making it structurally different from adult hemoglobin (HbA), which contains two beta chains. Sickle cell disease is caused by a mutation in the beta-globin gene, leading to the production of abnormal adult hemoglobin (HbS) that can polymerize under low oxygen conditions, causing red blood cells to sickle. Since HbF does not contain beta chains, it is not affected by the sickling mechanism of HbS, allowing individuals with higher levels of HbF to exhibit milder symptoms of sickle cell disease. This protective effect is why therapies aiming to increase HbF levels are being explored for sickle cell patients.


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Which blood cells are elevated at birth but decrease to adult levels in the first year of life?

Fetal hemoglobin (HbF) levels are elevated at birth and gradually decrease to adult levels within the first year of life. HbF is primarily found in fetal red blood cells and is gradually replaced with adult hemoglobin (HbA) as the infant grows.


How does fetal hemoglobin enhance oxygen transfer across placenta?

Fetal hemoglobin (HbF) has a higher affinity for oxygen compared to maternal hemoglobin (HbA), allowing it to effectively extract oxygen from the maternal blood in the placenta. This enhanced affinity is primarily due to HbF's reduced ability to bind 2,3-bisphosphoglycerate, which stabilizes the deoxygenated form of hemoglobin. As a result, HbF can capture more oxygen even at lower partial pressures, facilitating efficient oxygen transfer during fetal development. This mechanism ensures that the developing fetus receives adequate oxygen for growth and metabolic needs.


What is the special type of hemoglobin present in fetal RBC?

Fetuses possess a different type of haemoglobin to their mothers - HbF rather than HbA. The purpose of this is to allow the developing infant to 'steal' oxygen from it's mother. This normally has no adverse effects on the pregnant woman other than perhaps feeling a little breathless after mild exercise. HbF has what is described as a 'greater affinity for oxygen' and a 'lower affinity for carbon dioxide' to HbA. This allows the fetus to load oxygen and unload carbon dioxide with more ease than the mother, and so ensuring survival.


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