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Functions of hypocretin Apart from their primary role in the control of sleep and arousal, the hypocretins have been implicated in multiple functions including feeding and energy regulation, neuroendocrine regulation, gastrointestinal and cardiovascular system control, the regulation of water balance, and the modulation of pain. A role in behaviour is also postulated. The cell bodies responsible for hypocretin synthesis are localized to the tuberal part of the hypothalamus, the so-called feeding centre. The observation that Hcrt-1 increases metabolic rate and the demonstration that insulin-induced hypoglycaemia activates up to one-third of hypocretin containing neurons has led to the suggestion that the hypocretins are mediators of energy metabolism. The neuroendocrine effects of the hypocretins include a lowering of plasma prolactin and growth hormone and an increase in the levels of corticotropin and cortisol, insulin and luteinizing hormone. Central administration of the hypocretins increases water consumption, stimulates gastric acid secretion and increases gut motility. The hypocretins increase mean arterial blood pressure and heart rate. The localization of long descending axonal projections containing hypocretin at all levels of the spinal cord suggests a role in the modulation of sensation and pain. Strong innervation of the caudal region of the sacral cord suggests a role in the regulation of both sympathetic and parasympathetic functions.
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What is a change in the normal confirmation of a protein that often results in loss of protein function called?
That protein is called denatured.
What is the principle function of dietary carbohydrates to provide?
The principle function of dietary carbohydrates is to provide energy. Dietary sugars and starches are called protein sparing. A dietary protein can be used for protein synthesis and other vital processes.
What part of the brain causes narcolepsy?
A lack of the protein hypocretin in the hippocampus and lower thalamus is thought to be the location of the main cause of narcolepsy.
What is the function Heat shock protein?
function Heat shock protein
Definition structure function and biogenesis of microfilament?
The definition of a microfilament is a stringy protein found in most cells. The structure of a microfilament is a long, thing string-like protein and its function is to help the cell move. The biogenesis of a microfilament is a protein called actin.
Why does a denature protein no longer function normally?
the function of each protein is a consequence of its specific shape, which is lost when a protein becomes denatured.The shape of a protein determines its specific function within a cell. Denaturing a protein will alter its shape, thus it will no longer function.
Is a denatured protein able to function?
The function of each protein is a consequence of its specific shape, which is lost when a protein denatures.
What happens if a protein does not get into the correct shape?
A protein cannot perform its biological function, if it is not in the correct shape. Sometimes an incorrectly folded protein will become a very dangerous toxin called a prion.
Can you Describe how the amino acids changes in the protein affect the function of the protein and how this causes disease?
Can you describe how the amino acid changes in the protein affects the function of the protein?
What is the characteristic of protein?
analysing the function of a particular protein is protein characterization.
Which molecules coded by genes on chromosomes determine cell structure and function?
Genes copied from DNA are copied to RNA in a process called transcription. The RNA transcripts are then used in a process called translation, in which a code that determine the sequence of amino acids is translated to form a protein. The structure of the resulting protein determines the role of the protein in body structure and function...and ultimately, the structure and function of the body.
What do you call the process by which acid uncoils a protein molecule?
This process is called denaturation. It can be caused by acids, bases, organic solvents, or heat. When denaturation occurs, it changes the shape of the protein. Since form follows function, a protein's function is disabled if it no longer has the form required to carry out its tasks.
