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Many might answer, "murder," here. Many would be wrong for such. The ultimate, greatest sin is denying God.

Ultimate Sin is also the fourth studio album by the British heavy metal vocalist Ozzy Osbourne.

Another Answer: The ultimate sin of The Bible is sinning against the holy spirit. Matthew 12:31, 32 reads: ""For this reason I say to you, every sort of sin and blasphemy will be forgiven men, but the blasphemy against the spirit will not be forgiven. For example, whoever speaks a word against the Son of man, it will be forgiven him; but whoever speaks against the holy spirit, it will not be forgiven him, no, not in this system of things nor in that to come."

Since the holy spirit is what God uses to accomplish his purposes, sinning against that would be knowingly and willfully pitting yourself against the purposes of God. The Devil and his demons are among those who have sinned against the holy spirit because they deliberately pitted themselves against God. As far as which humans have done this, we cannot say for certain because that is up to God.

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10y ago

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