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Interstate 81, Harrisonburg, VA 22802
It's about 70 miles from Knoxville to Crossville, going via Interstate 40. The closest city to a halfway point along that route is Kingston, which is 36 miles from Knoxville and about 35.5 miles from Crossville.
Birmingham, Alabama is halfway between Knoxville & Jackson
The halfway point between Rochester, NY and Knoxville, TN is Columbus, OH.
A halfway point between Crossville, TN and Fayetteville, NC (depending on your route) is Vein Mountain, NC.
The halfway point between Barling Arkansas and New Orleans Louisiana is Port Union Louisiana traveling Interstate 55.
The halfway point between Fort Meyers, Florida and Knoxville, TN falls in or around Tifton, Georgia.
The halfway point between Evensville Tennesee and Knoxville Tennesee is Dogwood Shores Tennessee.
Knoxville, TN
Knoxville, Tennessee is about halfway between these two points.
Atlanta
Salem, VA