If Driving, the halfway point would be in-between Nashville, TN and Memphis, TN. There is no good town indicator. Mile 143 on I-40 might be a good halfway point.
Portland, TN
Wildersburg, TN
Vicksburg, Mississippi
The halfway point between Tulsa, Oklahoma, and Vicksburg, Mississippi, is Conway, Arkansas, if you're going via Fort Smith, Little Rock, and Pine Bluff.
I am pretty sure your answer is the Arkansas river.
Vicksburg is a large town on the Mississippi River about halfway up the state of Mississippi. It is best known for a major civil war battle
Halfway between Columbus and Cincinnati
One halfway point between the city of Little Rock, AR and Lewistown, PA would be Cincinnati, Ohio. Cincinnati, Ohio is close to Northern Kentucky which has many things to do.
Vicksburg
Thornton, IN
Mississippi
Between Glasgow, Kentucky and Louisiana the halfway point is Como Mississippi.
Evansville Indiana
Atlanta, GA is halfway between Ocala FL and Cincinnati OH