On a major road, and also roughly on a straight line, it is Greenville MS.
The exact midpoint is near Eudora, Arkansas (SW across the Mississippi River).
Greenville is on the Mississippi River, but not any interstate highways, so alternatives could be
Shreveport LA (on hwys 20 and 49)
Memphis TN (on hwys 30/40 and 55)
Jackson MS (on hwys 20 and 55).
The total distance is 822 miles, so the halfway point is 411 miles, which is just past the Mississippi River, right around Refuge, MS.
Gramblin, LA
Hickory Hills, Mississippi is halfway between Destin & Livingston
Atlanta, GA is the halfway point between Greensboro, NC and Destin, FL.
The halfway point is Jamestown, IN.
What is the half way point between Marion Ill. and Destin Florida
tuti
Athens, GA is the halfway point between Destin FL and Virginia. There are many hotels and places to eat there making it a good stop over point or place to meet up.
The halfway point between Omaha and Red Oak (taking I-29 south to US-34) is Glenwood, Iowa.
Le Claire, IA
Fruita, CO
Sterling, CO
davenport
Concordia MO