It depends on what you define "Middle America" as. If you define "Middle America" as the middle of the United States of America, then Chicago, Illinois would be the largest city with a population of 2.7 million people. If "Middle America" is the middle of the North American continent, then the twin cities of Minneapolis and St. Paul would be the largest city in that case (with a joint population of 3.28 million).
Mexico City
Mexico - North America's largest city, Mexico City, is located in Mexico. It is also the world's second-largest city.
Lima is the fourth largest city in South America. The largest city in South America is Sao Paulo in Brazil.
Mexico (Mexico City is the largest city in North America).
Mexico City is the largest city in North America by population.
Sao Paulo, Brazil is South America's largest city.
Mexico City is the largest city in North America by population.
The largest city that is located in Central America is Guatemala City. The next largest cities are Managua, Tegucigalpa, and Panama City.
The answer is the United States of America and Mexico. New york city is the largest and Mexico City is the second largest.
Mexico City, Mexico is the largest city in North America. Jakarta, Indonesia is the second largest city in the world.
New York City is the largest city in US, and the second largest city in North America. Mexico City is the largest. Toronto Is the largest city in Canada, and the fifth largest city in North America, after Los Angeles and Chicago.