About 35% of affected individuals have the childhood or adolescent cerebral form of ALD, which is the most severe. Age of onset ranges from four to ten years, with initial symptoms of behavioral changes, hyperactivity, and learning problems
The most severe form of adrenoleukodystrophy is known as cerebral adrenoleukodystrophy (CALD). This form primarily affects the brain and progresses rapidly, leading to severe neurological symptoms such as loss of cognitive function, movement disorders, and ultimately disability or death. Early detection and treatment are critical in managing CALD.
ALD is found in all ethnic groups. About one in every 100,000 people suffers from ALD. Because the most severe form, called classic ALD, is X-linked, many more males than females are affected.
The childhood form of the disease is the classical form and is the most severe. Childhood ALD is progressive and usually leads to total disability or death. It affects only boys because the genetic defect is sex-linked.
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Yes. Tornadoes are the most dangerous form of severe weather.
glioblastoma multiforme
Severe thunderstorms
Meningomyelocele is the most severe form of Spina Bifida.
The most common type of ALD (adrenoleukodystrophy) is X-linked ALD. Than means that the gene for ALD is on the X chromosome. Because boys have only one X chromosome, if it has the ALD gene on it they will have the disease. Girls have two X chromosomes, so, in order to get ALD both of their X chromosomes would have to have an ALD gene. That would mean that both her father and her mother would have to have an ALD gene. Because males with ALD die before they can have children this would not happen. So girls don't get this type of ALD. There are other, more rare types of ALD that affect both boys and girls. So, all in all, fewer girls have ALD
To have scientists collaborate to help find a therapy for ALD
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If a person has suffered from thyroid cancer, and has had their thyroid gland surgically removed in order to treat the cancer, that person would then have the most severe form of hypothyroidism, which is to have no thyroid gland at all.