In Tay- Sach's disease, hydrolysis of GM2-ganglioside requires 3 proteins.
Two of them are subunits of hexosaminidase A, and the third is a small glycolipid transport protein, the GM2 activator protein (GM2A), which acts as a substrate specific cofactor for the enzyme. Deficiency in any one of these proteins leads to storage of the ganglioside, primarily in the lysosomes of neuronal cells. Tay-Sachs disease (along with GM2-gangliosidosis and Sandhoff disease) occurs because a genetic mutation inherited from both parents deactivates or inhibits this process. Most Tay-Sachs mutations appear not to affect functional elements of the protein. Instead, they cause incorrect folding or assembly of the enzyme, so that intracellular transport is disabled.
recessive
the job is to produce proteins
the job is to produce proteins
chaperon protiens
they assemble proteins
the job of the ER is to produce proteins and lipids
PROTEINS
To recognize antigens.
To recognize antigens.
to create proteins and control the cell
It forms bones and muscles
golgi