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"Also note that the way the tests are set up, the serum screening test has a 5 to 8% false-positive rate (see above for the discussion of what this means) and also has a false-negative rate of 35 to 40%, and so will only detect about 60 to 65% of all fetuses with Down syndrome"

It will likely vary based on the mother's age however.

Source:

1) http://www.childbirthsolutions.com/articles/pregnancy/downtesting/index.php

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Q: What is the percentage of false-positive blood tests for Down syndrome?
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