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What is the reason why pilocarpine and carbachol used in treatment of glaucoma?
Wiki User
∙ 13y ago
First to clarify, Pilocarpine and carbachol are only used with open-angle glaucoma, which is the most common (~90% of US population) type and it's progressive. It will not be given to a patient with closed-angle glaucoma, an acute angle closure which requires ocular emergency. So these drugs cause ganglionic stimulation of Ach release in the Parasympathetic NS. Pilocarpine is a natural alkaloid that acts as a muscarinic agent and Carbachol is a direct-acting cholinomimetic that acts as a strong nicotinic agonist.
Glaucoma is a disease in which the optic nerve is damaged, leading to progressive irreversible loss of vision. It is often, but not always, associated with increased pressure of the fluid in eye. With this association in mind, and knowing that one of the functions of the PNS is to lower intraocular pressure, it would make sense to conclude these two drugs which stimulate the PNS by acting at the ganglion receptors would produce the response to relieve the effects of open-angle glaucoma.
Hope this helps!
Wiki User
∙ 13y ago
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