It is 415.33 miles according to MapQuest
The distance between Charlotte FL and Orlando FL is about 140 road miles.
The distance between Destin FL and Louisville KY is about 621 road miles.
The driving distance is 47.5 road miles.
Atlanta, GA to Destin, FL is 315 road miles.
The distance between Cincinnati OH and Destin FL is about 715 road miles.
The driving distance from Clearwater FL to Orlando FL is 106 road miles.
The distance is 55 road miles.
The distance between Ft. Lauderdale and Orlando is about 212 road miles.
The distance between Milwaukee WI and Orlando FL is about 1,242 road miles.
The driving distance is about 106 road miles.
The driving distance from Destin FL to Tampa FL is 437 road miles - about 7.5 hours driving time.It is 433 miles according to Google Maps.