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  1. Take I-26 WEST to I-40 WEST to CANTON and KNOXVILLE at EXIT 31B in North Carolina.
  2. Take I-40 WEST to TN-155 (BRILEY PKWY) NORTH at EXIT 215B. On I-40 in Tennessee, you will bypass Knoxville by taking I-640 WEST (EXIT 393 off I-40).
  3. Take TN-155 (BRILEY PKWY) NORTH to I-24 WEST to CLARKSVILLE at EXIT 18A.
  4. Take I-24 WEST to U.S. 60 and I-24 BUS. to PADUCAH and WICKLIFFE at EXIT 4 in Kentucky.
  5. Turn left off the exit ramp onto U.S. 60 WEST to WICKLIFFE. Take U.S. 60 WEST to I-44 via MO-360 in Missouri. Follow signs.
  6. Once you are at I-44, take I-44 WEST to TULSA.
  7. Take I-44 WEST to Joplin.
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Q: What is the shortest driving route from Charleston SC to Joplin MO?
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