The quickest and shortest route is I-5 North.
The shortest distance is via route US-72 E. The shortest time is via route I-40 E and I-24 E.
From Florida to Texas via the shortest route - you would pass through... Alabama, Mississippi, and Louisiana.
To drive it there the shortest route is to use the Hollyhead Ferry.
US 93 North for 285 miles and about a 5 hour drive.
The distance from Baltimore, MD to Myrtle Beach, SC is about 487.2 miles (according to the shortest route on Mapquest).
The shortest route is about 50km and a 45 minute drive.
Driving the I-95 between Baltimore and Miami is the fastest route. It is about 1100 miles and will take about 17 hours driving non-stop.
35 hours
I-95 South ... approximately a 12 hour drive.
I-80 west
According to Mapquest, it would take about 1 hour and 37 minutes to drive the shortest route.