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First, the term machine pistol must be defined, to separate these from Personal Defense Weapons and submachine guns. If you consider that it is a handgun designed to fire a pistol cartridge in a fully automatic or burst fire mode, then a likely candidate would be any gun chambered in 10mm (700 ft lbs muzzle energy) followed by the .40 S&W or the .38 Super (500 ft lbs) However, in 1935, Remington made a special .45 ACP cartridge to be fired from the Thompson- and one version of the Thompson IS called a machine pistol- and the .45 Remington-Thompson cartridge was rated at 1,050 ft lbs of energy. Most machine pistols in 9mm Parabellum or 9mm Makarov have much less power.

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11y ago
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Q: What is the world's most powerful machine pistol?
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