130-0 vs Michigan on October 22, 1904.
Wisconsin
1996 they lost to Ohio State 72-0.
Any loss to Iowa State is arguably the worst loss ever.
The loss of dignity and innocence for the whole program in 2011. Or the 79 Sugar Bowl.
James Madison
There worst lost was against the timberwolves
67-28-5 UofM
The Oklahoma City Bombing.
The Wolverines lead 67-29-5
As of the start of the 2008 season, Michigan's all time win loss record is 869-286-36.
Australia 31-0 American Samoa