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Most nuclear power stations run on enriched uranium in one form or another, either as uranium compounds, or as uranium metal. Some use other fuels, but all plants based on nuclear fission use fuels based either thorium or uranium, which are the only fertile element found in any abundance in nature. Fusion plants are envisioned, but none has been designed so far; these would use isotopes of hydrogen for fuel.

To get enriched uranium, ore has to be mined, and the uranium in it extracted and refined. The resulting uranium is usually about 99.28% made up of 238U, and 0.71% of 235U. In order to be used in most conventional nuclear plants the 235U has to be increased to 3% to 5% of the total. There are various ways of doing this, but the commonest seems to be to react the uranium, making UFl6, uranium hexafluoride, which is a gas, and concentrate the lighter portions in a centrifuge at very high speeds. The enriched UFl6 is then reacted to form the form of uranium needed for the particular design of the power plant.

In most plants, the uranium is packaged in rods, enclosed in sheathing of some special material such as zirconium. These are assembled in bundles that can be put into and taken out of the reactor relatively easily.

There are other ways of fueling nuclear reactors. But this is the most common.

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