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What may happen if microtubules collapse to cause Alzheimer's disease?
Wiki User
∙ 12y ago
Another hallmark of Alzheimer’s disease is the presence of neurofibrillary tangles inside neurons. These involve a protein called tau, which functions like railroad ties to bind microtubule “tracks” together. In the brains of AD victims, tau abandons its microtubule-stabilizing role and grabs onto other tau molecules, forming spaghetti-like neurofibrillary tangles, which kill the neurons by disrupting their transport mechanisms. As the brain cells die, the brain shrinks. Loss of neurons in the basal forebrain is associated with a shortage of the neurotransmitter acetylcholine, and drugs that inhibit breakdown of acetylcholine slightly enhance cognitive function in AD patients.
Wiki User
∙ 15y ago
Wiki User
∙ 12y agoloss of memory
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