It basically means that your adrenaline production is high.
Norepinephrine is made from dopamine in the medulla of the adrenal gland.
It is a norepinephrine reuptake inhibitor. Norepineprhine is a stimulating neurotransmitter. It makes you feel up, energetic, and hyperactive. It also increases your heart rate and blood pressure. When norepinephrine is released from nerve cells in the synapse to send a signal on to the next nerve cell, there is a reuptake pump that removes the norepinephrine to cut the signal off. This keeps the pathway from firing to much or too long and preserves the norepinephrine for future use. Cocaine blocks the reuptake system and makes the stimulating stronger and last longer. However it that means that you also deplete your supply of norepinephrine and "crash". This makes you feel tired. So you keep wanting more cocaine to get back to that good (high) feeling, but because you have used up the norepinephrine you never quite reach it. That makes cocaine very addictive.
epinepherine and norepinephrine
The adrenal gland makes and secretes norepinephrine and also converts some norepinephrine into epinephrine and secretes that.
Norepinephrine is released from the sympathetic nervous system. Norepinephrine is a stress hormone which affects parts of the brain and causes the heart to beat more rapidly.
Sympathetic postganglionic neurons release norepinephrine,
Norepinephrine is made from dopamine in the medulla of the adrenal gland.
epinephrine and norepinephrine stimulate the sympathetic nervous system
The S stands for serotonin and the N stands for norepinephrine and RI stands for reuptake inhibitor. So, obviously these drugs are supposed to work on both serotonin and norepinephrine. However, some literature uses SNRI to mean Selective Norepinephrine Reuptake Inhibitor, and this will work better on norepinephrine. Then you have the SSRI which is Selective Serotonin Reuptake Inhibitor, which works better on serotonin.
Amphetamines are psychostimulant drugs of abuse and include methamphetamine, amphetamine and ecstacy or MDMA. Amphetamine drugs can effect norepinephine in several ways. Initially amphetamine drugs will cause a massive release of all monoamine neurotransmitters (dopamine, serotonin and norepinephrine) from the vesicles inside the presynaptic cleft of a neuron. Furthermore, amphetamine and methamphetamine (not MDMA) are very structurally similar to norepinephrine and can substitute, or move through, the norepinephrine transporter (NET) which regulates the amount of norepinephrine in the synapse. This can lead to dysregulation of the transporter so that it no longer functions properly. This can happen in several ways including internalization of the transporter inside the presynaptic cleft and/or phosphorylation of the transporter, which can essentially shut it off. This means that there is more norepinephrine in the synapse, which can bind to norepinephrine receptors and lead to the subjective (feeling), physiological, behavioral and neurobiological effects of amphetamine drugs.
epinephrine and norepinephrine
An overabundance of the neurotransmitter norepinephrine is most likely to be associated with manic episode.