It basically means that your adrenaline production is high.
Foods high in tyrosine, such as poultry, seafood, tofu, seeds, and dairy products, can stimulate the production of norepinephrine. Additionally, foods rich in vitamin C, such as citrus fruits, peppers, and strawberries, can help support the synthesis of norepinephrine in the body.
Norepinephrine is made from dopamine in the medulla of the adrenal gland.
It is a norepinephrine reuptake inhibitor. Norepineprhine is a stimulating neurotransmitter. It makes you feel up, energetic, and hyperactive. It also increases your heart rate and blood pressure. When norepinephrine is released from nerve cells in the synapse to send a signal on to the next nerve cell, there is a reuptake pump that removes the norepinephrine to cut the signal off. This keeps the pathway from firing to much or too long and preserves the norepinephrine for future use. Cocaine blocks the reuptake system and makes the stimulating stronger and last longer. However it that means that you also deplete your supply of norepinephrine and "crash". This makes you feel tired. So you keep wanting more cocaine to get back to that good (high) feeling, but because you have used up the norepinephrine you never quite reach it. That makes cocaine very addictive.
Norepinephrine is released from the sympathetic nervous system. Norepinephrine is a stress hormone which affects parts of the brain and causes the heart to beat more rapidly.
Sympathetic postganglionic neurons release norepinephrine,
Norepinephrine is primarily broken down by the enzyme monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) in the liver and other tissues. MAO oxidizes norepinephrine into its metabolite, dihydroxyphenylglycol (DHPG), while COMT methylates norepinephrine into normetanephrine.
epinephrine and norepinephrine stimulate the sympathetic nervous system
Andrenergic fibers release Norepinephrine and Cholinergic fibers release Acetylcholine.
The final step in the release of norepinephrine from the sympathetic neuron involves the fusion of vesicles containing norepinephrine with the cell membrane, leading to the release of norepinephrine into the synaptic cleft. This process is triggered by an action potential reaching the nerve terminal.
The S stands for serotonin and the N stands for norepinephrine and RI stands for reuptake inhibitor. So, obviously these drugs are supposed to work on both serotonin and norepinephrine. However, some literature uses SNRI to mean Selective Norepinephrine Reuptake Inhibitor, and this will work better on norepinephrine. Then you have the SSRI which is Selective Serotonin Reuptake Inhibitor, which works better on serotonin.
Norepinephrine primarily acts as a vasoconstrictor and can increase heart contractility, which typically leads to an increase in cardiac output. However, in certain situations, such as when there is excessive vasoconstriction or under conditions of high vascular resistance, it may indirectly contribute to a decrease in stroke volume by reducing venous return. Overall, the effect of norepinephrine on stroke volume can vary depending on the physiological context.
Amphetamines are psychostimulant drugs of abuse and include methamphetamine, amphetamine and ecstacy or MDMA. Amphetamine drugs can effect norepinephine in several ways. Initially amphetamine drugs will cause a massive release of all monoamine neurotransmitters (dopamine, serotonin and norepinephrine) from the vesicles inside the presynaptic cleft of a neuron. Furthermore, amphetamine and methamphetamine (not MDMA) are very structurally similar to norepinephrine and can substitute, or move through, the norepinephrine transporter (NET) which regulates the amount of norepinephrine in the synapse. This can lead to dysregulation of the transporter so that it no longer functions properly. This can happen in several ways including internalization of the transporter inside the presynaptic cleft and/or phosphorylation of the transporter, which can essentially shut it off. This means that there is more norepinephrine in the synapse, which can bind to norepinephrine receptors and lead to the subjective (feeling), physiological, behavioral and neurobiological effects of amphetamine drugs.