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there are a lot of medication options. And something else to consider is that narcoleptics often suffer from additional issues like: restless legs syndrome, apnea, and cataplexy, which may require their own medications. I have been diagnosed with narcolepsy for over 12 years and in that time i have taken Ritalin: This did keep me awake but i had to take it 3 times a day, and I wasn't great about taking them at the exact right times. And if i didn't take them at the exact time i was supposed to, i would really feel a "crash". I decided that the ups and downs were to extreme. But many people take it and it works for them. I think it's important to learn about the options and then try one and see how it works for YOU. Everyone responds differently. Dexedrine: this worked well to keep me awake but I occasionally felt like i was buzzing and I didn't like the research that i was reading about the affects that amphetimenes can have on your body. So i looked for an alternative. Provigil: much better! This is great for me, it is not an amphetimine and I think it does a much better job of keeping me awake and stablized. I currently take a generic version that is 100% fine. Unfortunately the greedy drug manufacturing companies in the US have actually paid generic drug manufacturers NOT to make a generic of provigil, so i have to order it from Canada. The price is much better and the quality is the same, they mail the pills to me, and the customer service is fantastic.

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16y ago
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13y ago

Doctors prescribe various medications to treat the symptoms of narcolepsy. The most common symptom is excessive daytime sleepiness, so most patients will have some type of stimulant. Provigil and Nuvigil are excellent stimulants because they are effective central nervous stimulants that do not elevate the heart rate. Amphetamines may also be prescribed.

Other symptoms require other medications. Patients with cataplexy sometimes see results from taking antidepressants.

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Q: What medications work best for narcolepsy?
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Not at this time, no. However, there are medications that can help with the symptoms.


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Medications include antidepressants (tricyclic antidepressants or SSRIs) treat cataplexy, hypnagogic hallucinations, sleep paralysis and stimulants (amphetamines) may increase alertness.


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I think it depends on severity of your condition. I have narcolepsy and the 150mg do not last throughout the day, but if I take the 250mg around 5:30am before work, I'm good for the day and have no side effects whatsoever. If my doctor hadn't had narcolepsy himself, he maynot havediagnosed my narcolepsy right away.


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The two medications work best when taken alternately instead of both on the same day.


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