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What might cause a protein to become nonfunctional?

Updated: 9/17/2019
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Q: What might cause a protein to become nonfunctional?
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How might nucleotide insertion cause a change in amino acids?

Nucleotides are read in groups of three, and inserting a nucleotide will mess up the process. Think of the sentence: "She did not eat the pie". If you insert a letter, everything up to that point will be the same, but the spacing afterwards will be off: "She did nzo tea tth epi e". This will cause all of the amino acids after that point to be incorrect, and the resulting protein to be nonfunctional.


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