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What occurs if a T cell binds to an antigen and the T cell does not receive a co-stimulatory signal?
Wiki User
∙ 12y ago
The T cell enters a state of anergy. In this case, the T cell becomes tolerant to that antigen and is unable to divide or to secrete cytokines. This state of unresponsiveness to antigen is called anergy.
Wiki User
∙ 12y ago
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Is T cell activation antigen specific?
Yes. The first signal that a T cell receives from an antigen presenting cell (dendritic cell) is MHC presenting an antigen (foreign peptide). This gives the T cell specificity to this antigen.
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What occurs if a t cell binds to an antigen and the t cell does not receive a costimulatory signal?
The T cell enters a state of anergy
Is T cell activation antigen specific?
Yes. The first signal that a T cell receives from an antigen presenting cell (dendritic cell) is MHC presenting an antigen (foreign peptide). This gives the T cell specificity to this antigen.
What are the double signals in T cell activation?
T cells receive 3 signals during activation:1. Major Histocompatibility Complex (MHC) presenting an antigen (foreign peptide) to the T cell receptor2. The co-stimulatory signal (B7 on the dendritic cell binding to CD28 on the T cell)The first signal ensures that the T cell is specific for the antigen it has been presented.The T cell cannot be activated without also recieveing the second signal. This is how the T cell checks that it has been presented an antigen by a "professional" antigen presenting cell.3. Cytokines (signalling molecules) are released by the dendritic cell - these cause the differentiation of the T cell
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The first signal required to activate a T cell is MHC(Major Histocompatibility Complex) presenting an antigen(foreign peptide) to the T cell receptor.
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