Those who are very elderly, demented, or with other significant medical conditions that would be compromised by surgery are usually not candidates for pallidotomy.
Studies show the procedure generally improves tremor, rigidity, and slowed movements by 25-60%.
Pallidotomy is major surgery on the brain. It may cause excessive bleeding, and care must be taken in patients susceptible to uncontrolled bleeding or who are on anticoagulant therapy.
Patients will feel improved movement immediately.
Most patients gain weight after surgery.
Pallidotomy takes several hours to perform. In some medical centers, pallidotomy is performed as an outpatient procedure, and patients are sent home the same day. Most centers provide an overnight stay or longer for observation and recuperation
Pallidotomy is performed in patients with Parkinson's disease who are still responsive to levodopa, but who have developed disabling drug treatment complications known as motor fluctuations.
Some cognitively fragile patients may become even more impaired after surgery.
Pallidotomy is performed in the hospital by a neurosurgeon, in coordination with the patient's neurologist.
For unilateral pallidotomy, a single "burr hole" is made in the top of the skull; bilateral pallidotomy requires two holes.
Hemorrhage may occur in 2-6%, visual field deficits in 0-6%, and weakness in 2-8%.
Hemorrhage may occur in 2-6%, visual field deficits in 0-6%, and weakness in 2-8%.
Pallidotomy mimics this action by permanently destroying the GPi cells.