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Losing around 20% of your blood volume will put you into shock.

NB: When your blood pressure falls, your body is unable to compensate through the normal mechanisms of control (such as the renin-angiotensin system in the kidneys, or constricting blood vessels) for the the loss of blood and the patient is in serious shock. If the blood loss is acute, the BP may rise initially due to the constriction of blood vessels etc.

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Q: What percent of blood volume loss is necessary for significant vital sign change?
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