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All White House important appointments require senate approval ( US Constitution Article II Section 2) The Senate majority is not always of the same party as the President and they do not always go along with the President's choices. They are not always forgiving of a nominee who has crossed some of the Senate leaders in the past. In short, partisan politics can make it impossible for the President to make the appointments he wants to make.
A related practice is the fact that some of the less important ambassador positions and some of the lesser cabinet posts are after used to reward big campaign contributors. An unfriendly Senate can block such appointments or else demand some kind of concession or trade-off in exchange for their approval.
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