What problem might arise in histone-deficient chromatin?

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April 03, 2007 2:09AM

Histones function in the packaging of DNA as well as in regulation of gene expression in eukaryotic (and some bacterial) cells. Histone proteins are among the most highly conserved proteins in eukaryotes, emphasizing their requirement for the survival of more complex life forms. Cells deficient in histones likely would not survive as the complex genomes of eukaryotes would not have the necessary levels of regulation as well as the DNA would not be efficiently packed and would be fragile and highly susceptible to damage.