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The mouth increases the surface area of the food so that it will be easier to be digested in the stomach/small intestine. The stomach breaks down proteins and makes the food acidic, while the small intestine breaks down fats, lipids, and proteins and makes the food return to a normal pH. The liver synthesizes bile, which serves as an emulsifier, which means that it breaks down the fat by increasing the surface area to volume ratio.

Those are probably the "main ones", but there are other important ones like the large intestine.

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